Original name: Peter Dinklage

Character: Winston Gooze / Toxie (voice)

Original name: Jacob Tremblay

Character: Wade Gooze

Original name: Taylour Paige

Character: J.J. Doherty

Original name: Julia Davis

Character: Kissy Sturnevan

Original name: Jonny Coyne

Character: Thad Barkabus

Original name: Elijah Wood

Character: Fritz Garbinger

Original name: Kevin Bacon

Character: Bob Garbinger

Original name: David Yow

Character: Guthrie Stockins

Original name: Sarah Niles

Character: Mayor Togar

Original name: Shaun Dooley

Character: Mel Ferd

Original name: Luisa Guerreiro

Character: Toxic Avenger/Toxie

Original name: Spencer Wilding

Character: Monster Garbinger

Original name: Atanas Srebrev

Character: Chief Wormer

Original name: Abraham Lewis

Character: Spence

Original name: Lee Eddy

Character: CJ Doons

Original name: Annette Badland

Character: Daisy

Original name: Sunil Patel

Character: Dr. Walla

Original name: Rebecca O'Mara

Character: Shelly Gooze

Original name: Julian Kostov

Character: Budd Berserk

Original name: JR Esposito

Character: J.R. Gile

Original name: Brent Werzner

Character: Toxie Witness

Original name: Macon Blair

Character: Dennis

Original name: Lloyd Kaufman

Character: Lloyd (The Hospital Grump)

Original name: Jane Levy

Character: Cheerful Insurance Rep (voice)

Original name: Margo Cargill

Character: Agent Sarah Weatherwax

Original name: Chris Sharp

Character: C.S. Hawley

Original name: Randy E. Aguebor

Character: Coach Stanwyck

Original name: Ev Lunning

Character: Rick Feet

Original name: Byron Brown

Character: Sad Commercial Man